[PDF] Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients | Semantic Scholar (2024)

[PDF] Semantic Reader

The goal of this study was to investigate the potential overlap between parameters of protein complexes (eg, ICs or avidin-biotin complexes) and MPs, which might perturb detection and/or isolation of MPs.

The view that whereas small size circulating immune complexes are of no primary pathogenic importance in synovitis, large size (greater than 22S) circulatingimmune complexes may play a role in extra-articular disease in RA is supported.

The results suggest that the influence of a nonionic polymer or plasma protein on RBC aggregation is simply a consequence of its size in an aqueous environment, and that the specific type of macromolecule is of minor importance.

Testing RF allows the highest sensitivity, while IgA isotype the highest specificity and positive likelihood ratio for RA diagnosis, while analysing anti-citrullinated protein antibodies do not provide relevant prognostic information, as results are conflicting.

Comparing the capability of IgA and IgG complexes formed by heat aggregation to induce NET formation shows that IgA is a much more potent inducer of NET formation than IgG, and may be the main driving force in (auto)immune complex-mediated NET formation.

The history of the ADE phenomenon is explored, the diversity of immune responses mediated upon FcγR engagement is discussed and the available experimental evidence supporting the role of F cγRs in antiviral protection and pathogenesis through ADE is reviewed.

A critical review of the characteristics and possible biological effects and mechanisms of the immunopathogenesis of ACPAs in patients with RA is presented.

...

...